Template:PBB/6376

Chemokine (C-X3-C motif) ligand 1
PDB rendering based on 1b2t.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1B2T, 1F2L, 3ONA, 4XT1, 4XT3
Identifiers
Symbols	CX3CL1 ; ABCD-3; C3Xkine; CXC3; CXC3C; NTN; NTT; SCYD1; fractalkine; neurotactin
External IDs	OMIM: 601880 MGI: 1097153 HomoloGene: 2251 GeneCards: CX3CL1 Gene
Gene ontology Molecular function • receptor binding • protein binding • chemokine activity • CCR chemokine receptor binding Cellular component • extracellular region • extracellular space • plasma membrane • cell surface • integral component of membrane • cell projection • perinuclear region of cytoplasm Biological process • response to hypoxia • microglial cell activation • positive regulation of neuroblast proliferation • monocyte chemotaxis • chemotaxis • defense response • immune response • cell adhesion • G-protein coupled receptor signaling pathway • aging • positive regulation of macrophage chemotaxis • cytokine-mediated signaling pathway • platelet activation • neutrophil chemotaxis • leukocyte chemotaxis • positive regulation of transforming growth factor beta1 production • positive regulation of GTPase activity • positive regulation of angiogenesis • negative regulation of vasoconstriction • eosinophil chemotaxis • macrophage chemotaxis • lymphocyte chemotaxis • positive regulation of smooth muscle cell proliferation • negative regulation of cytokine secretion • positive regulation of inflammatory response • leukocyte adhesive activation • positive regulation of calcium-independent cell-cell adhesion • angiogenesis involved in wound healing • inhibitory postsynaptic potential • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6376	20312
Ensembl	ENSG00000006210	ENSMUSG00000031778
UniProt	P78423	O35188
RefSeq (mRNA)	NM_001304392	NM_009142
RefSeq (protein)	NP_001291321	NP_033168
Location (UCSC)	Chr 16: 57.37 – 57.39 Mb	Chr 8: 94.77 – 94.78 Mb
PubMed search	[1]	[2]