Template:PBB/85363

Tripartite motif containing 5
250px Rendering based on PDB 2ECV.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ECV, 2YRG
Identifiers
Symbols	TRIM5 ; RNF88; TRIM5alpha
External IDs	OMIM: 608487 MGI: 2441735 HomoloGene: 75345 GeneCards: TRIM5 Gene
EC number	6.3.2.-
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • zinc ion binding • signaling pattern recognition receptor activity • ligase activity • protein kinase binding • protein binding, bridging • identical protein binding • protein homodimerization activity Cellular component • cytoplasmic mRNA processing body • cytoplasm • cytosol • omegasome Biological process • activation of innate immune response • pattern recognition receptor signaling pathway • autophagy • viral process • cytokine-mediated signaling pathway • regulation of lipopolysaccharide-mediated signaling pathway • regulation of protein localization • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of MAPK cascade • innate immune response • negative regulation of viral entry into host cell • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • defense response to virus • interferon-gamma-mediated signaling pathway • protein trimerization • protein K63-linked ubiquitination • negative regulation of viral release from host cell Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE TRIM5 210705 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	85363	319236
Ensembl	ENSG00000132256	ENSMUSG00000057143
UniProt	Q9C035	n/a
RefSeq (mRNA)	NM_033034	NM_001146007
RefSeq (protein)	NP_149023	NP_001139479
Location (UCSC)	Chr 11: 5.66 – 5.94 Mb	Chr 7: 104.34 – 104.35 Mb
PubMed search	[1]	[2]