Transferrin receptor 2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Transferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2 gene.[1][2] This protein is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.
Function
This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[3]
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Further reading
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