PDGFRA

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Platelet-derived growth factor receptor, alpha polypeptide
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PDGFRA ; CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
External IDs OMIM173490 MGI97530 HomoloGene31361 ChEMBL: 2007 GeneCards: PDGFRA Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE PDGFRA 203131 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5156 18595
Ensembl ENSG00000134853 ENSMUSG00000029231
UniProt P16234 P26618
RefSeq (mRNA) NM_006206 NM_001083316
RefSeq (protein) NP_006197 NP_001076785
Location (UCSC) Chr 4:
54.23 – 54.3 Mb
Chr 5:
75.15 – 75.2 Mb
PubMed search [1] [2]

Platelet-derived growth factor receptor, alpha polypeptide is a protein that in humans is encoded by the PDGFRA gene.

Function

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.[1]

Interactions

PDGFRA has been shown to interact with:

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See also

References

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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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