Elotuzumab
Monoclonal antibody | |
---|---|
Type | Whole antibody |
Source | Humanized |
Target | SLAMF7 (CD319) |
Clinical data | |
Trade names | Empliciti |
Pregnancy category |
|
Legal status |
|
Routes of administration |
IV |
Pharmacokinetic data | |
Bioavailability | 100% (IV) |
Identifiers | |
CAS Number | 915296-00-3 ![]() |
ATC code | none |
IUPHAR/BPS | 8361 |
DrugBank | DB06317 ![]() |
UNII | 1351PE5UGS ![]() |
Chemical data | |
Formula | C6476H9982N1714O2016S42 |
Molecular mass | 145.5 kg/mol |
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Elotuzumab (brand name Empliciti, previously known as HuLuc63) is a humanized monoclonal antibody used in relapsed multiple myeloma.[1] The package insert denotes its mechanism as a SLAMF7-directed (also known as CD 319) immunostimulatory antibody.[2]
Approvals and indications
In May 2014, it was granted "Breakthrough Therapy" designation by the FDA. [3] On November 30, 2015, FDA approved elotuzumab as a treatment for patients with multiple myeloma who have received one to three prior medications.[1] Elotuzumab was labeled for use with lenalidomide and dexamethasone. Each intravenous injection of elotuzumab should be premedicated with dexamethasone, diphenhydramine, ranitidine and acetaminophen.[2]
References
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- Chemical articles having calculated molecular weight overwritten
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- Monoclonal antibodies for tumors
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