Figitumumab
Monoclonal antibody | |
---|---|
Type | Whole antibody |
Source | Human |
Target | IGF-1 receptor |
Clinical data | |
Legal status |
|
Identifiers | |
CAS Number | 943453-46-1 ![]() |
ATC code | none |
UNII | VE267FC2UB ![]() |
KEGG | D09345 ![]() |
Chemical data | |
Formula | C6462H9948N1736O2020S54 |
Molecular mass | 146.0 kg/mol |
![]() ![]() |
Figitumumab (previously CP-751871) is a monoclonal antibody[1] targeting the insulin-like growth factor-1 receptor that was investigated for the treatment of various types of cancer, for example adrenocortical carcinoma[2] and non-small cell lung cancer (NSCLC).[3]
This drug was being developed by Pfizer, but they ceased development of the drug in January 2011 and has stopped its manufacture.[4]
Anti-cancer mechanism
See Insulin-like growth factor 1 receptor role in cancer.
Clinical trials
The first phase III trial (for NSCLC) was suspended in December 2009 due to excess deaths[5] but others continued.[6][7]
It was to have been included in the I-SPY2 breast cancer trial.[8]
References
- ↑ Statement On A Nonproprietary Name Adopted By The Usan Council - Figitumumab, American Medical Association.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Clinical trial number NCT00976508 for "Figitumumab Combined With Pegvisomant For Advanced Solid Tumors" at ClinicalTrials.gov
- ↑ Clinical trial number NCT00635245 for "CP-751871 in Treating Women With Early-Stage Breast Cancer That Can Be Removed by Surgery" at ClinicalTrials.gov
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
<templatestyles src="Asbox/styles.css"></templatestyles>
<templatestyles src="Asbox/styles.css"></templatestyles>
- Chemical articles having calculated molecular weight overwritten
- Drugs that are a monoclonal antibody
- Articles without EBI source
- Chemicals that do not have a ChemSpider ID assigned
- Chemical pages without DrugBank identifier
- Articles without InChI source
- Drugs not assigned an ATC code
- Monoclonal antibodies for tumors
- Pfizer
- Experimental cancer drugs
- Monoclonal antibody stubs
- Antineoplastic and immunomodulating drug stubs