Figitumumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | IGF-1 receptor |
| Clinical data | |
| Legal status |
|
| Identifiers | |
| CAS Number | 943453-46-1  |
| ATC code | none |
| UNII | VE267FC2UB  |
| KEGG | D09345 |
| Chemical data | |
| Formula | C6462H9948N1736O2020S54 |
| Molecular mass | 146.0 kg/mol |
| (what is this?) (verify) |
|
Figitumumab (previously CP-751871) is a monoclonal antibody[1] targeting the insulin-like growth factor-1 receptor that was investigated for the treatment of various types of cancer, for example adrenocortical carcinoma[2] and non-small cell lung cancer (NSCLC).[3]
This drug was being developed by Pfizer, but they ceased development of the drug in January 2011 and has stopped its manufacture.[4]
Anti-cancer mechanism
See Insulin-like growth factor 1 receptor role in cancer.
Clinical trials
The first phase III trial (for NSCLC) was suspended in December 2009 due to excess deaths[5] but others continued.[6][7]
It was to have been included in the I-SPY2 breast cancer trial.[8]
References
- ↑ Statement On A Nonproprietary Name Adopted By The Usan Council - Figitumumab, American Medical Association.
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- ↑ Clinical trial number NCT00976508 for "Figitumumab Combined With Pegvisomant For Advanced Solid Tumors" at ClinicalTrials.gov
- ↑ Clinical trial number NCT00635245 for "CP-751871 in Treating Women With Early-Stage Breast Cancer That Can Be Removed by Surgery" at ClinicalTrials.gov
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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