Estrogen ester

From Infogalactic: the planetary knowledge core
Jump to: navigation, search

An estrogen ester is an ester of an endogenous, steroidal estrogen, generally estradiol but also estrone or estriol.[1] Esterification renders these drugs into metabolically-resistant prohormones of their respective parent estrogen, improving oral bioavailability, increasing lipophilicity, and extending half-life (which necessitates less frequent administration).[2] In addition, with intramuscular injection, they are absorbed more slowly into the body, further improving half-life.[1]

Estrogen esters are used in hormone replacement therapy and as hormonal contraceptives, among other indications.

The first estrogen ester to be marketed was estradiol benzoate in 1936,[3][4] which was quickly followed by many more.

List of estrogen esters

Many esters of estradiol have been marketed, including the following:[5][6]

As well as the following esters of other estrogens:[5][6]

A few other estrogen esters which are notable but have not been marketed include atrimustine (bestrabucil), estrapronicate, orestrate, which are estradiol esters.[6]

See also

References

  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ 5.0 5.1 Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ 6.0 6.1 6.2 Lua error in package.lua at line 80: module 'strict' not found.


<templatestyles src="Asbox/styles.css"></templatestyles>

Stub icon

This hormonal preparation article is a stub. You can help Wikipedia by expanding it.

<templatestyles src="Asbox/styles.css"></templatestyles>

Stub icon

This article about a steroid is a stub. You can help Wikipedia by expanding it.
Retrieved from "https://infogalactic.com/w/index.php?title=Estrogen_ester&oldid=720624238"