Interleukin-13 receptor
| interleukin 13 receptor, alpha 1 | |
|---|---|
| Identifiers | |
| Symbol | IL13RA1 |
| Alt. symbols | IL-13Ra, NR4, CD213a1 |
| Entrez | 3597 |
| HUGO | 5974 |
| OMIM | 300119 |
| RefSeq | NM_001560 |
| UniProt | P78552 |
| Other data | |
| Locus | Chr. X q24 |
| interleukin 13 receptor, alpha 2 | |
|---|---|
| Identifiers | |
| Symbol | IL13RA2 |
| Alt. symbols | IL-13R, IL13BP, CD213a2 |
| Entrez | 3598 |
| HUGO | 5975 |
| OMIM | 300130 |
| RefSeq | NM_000640 |
| UniProt | Q14627 |
| Other data | |
| Locus | Chr. X q13.1-q28 |
| interleukin 4 receptor | |
|---|---|
| Identifiers | |
| Symbol | IL4R |
| Alt. symbols | IL4RA; CD124 |
| Entrez | 3566 |
| HUGO | 6015 |
| OMIM | 147781 |
| RefSeq | NM_000418 |
| UniProt | Q9H186 |
| Other data | |
| Locus | Chr. 16 p12.1-11.2 |
The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively.[1][2] These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin.[citation needed]
There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. It acts as a negative regulator of both IL-13 and IL-4, however the mechanism of this is still undetermined.[3]
References
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- ↑ Seyfizadeh, N., Seyfizadeh, N., Babaloo, Z. (2014). "Interleukin-13 as an Important Mediator: A Review on its Roles in Some Human Diseases", Iranian Journal of Allergy, Asthma and Immunology, In Press.
External links
- Receptors, Interleukin-13 at the US National Library of Medicine Medical Subject Headings (MeSH)
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