MN1 (gene)

Meningioma (disrupted in balanced translocation) 1
Identifiers
Symbols	MN1 ; MGCR; MGCR1; MGCR1-PEN; dJ353E16.2
External IDs	OMIM: 156100 MGI: 1261813 HomoloGene: 37620 GeneCards: MN1 Gene
Gene ontology Molecular function • molecular_function Cellular component • cellular_component Biological process • intramembranous ossification • biological_process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4330	433938
Ensembl	ENSG00000169184	ENSMUSG00000070576
UniProt	Q10571	D3YWE6
RefSeq (mRNA)	NM_002430	NM_001081235
RefSeq (protein)	NP_002421	NP_001074704
Location (UCSC)	Chr 22: 27.75 – 27.8 Mb	Chr 5: 111.42 – 111.46 Mb
PubMed search	[1]	[2]

MN1 is a gene found on human chromosome 22, with gene map locus 22q12.3-qter. Its official full name is meningioma (disrupted in balanced translocation) 1 because it is disrupted by a balanced translocation (4;22) in a meningioma.

Function

MN1 is a transcription coregulator that enhances or represses RAR/RXR-mediated gene transcription through interaction with RAC3 and p300. MN1 also acts as a coactivator of the vitamin D receptor.

Clinical significance

Its inactivation may be part of the cause of certain meningiomas. A potential link to leukemia including acute myeloid leukemia has also been described.