Nuclear receptor coactivator 1
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The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.[1][2]
NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).
Interactions
Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:
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- Androgen receptor,[3][4][5]
- C-Fos,[6][7]
- C-jun,[6][7][8]
- CIITA,[9]
- CREB-binding protein,[10][11]
- Cyclin D1,[12]
- DDX17,[13]
- DDX5[13] and
- Estrogen receptor alpha,[10][13][14][15][16]
- Glucocorticoid receptor,[17][18]
- NFKB1,[6][19]
- PCAF,[20]
- PPARGC1A,[21]
- Peroxisome proliferator-activated receptor alpha,[22][23]
- SNW1,[24]
- STAT3,[25]
- STAT6,[26][27]
- TRIP4,[28] and
- Thyroid hormone receptor beta.[29][30]
References
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External links
- nuclear receptor coactivator 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C89
Further reading
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