NCOA6
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[1][2][3]
Function
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[3]
Interactions
NCOA6 has been shown to interact with:
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- ASCL2[4] and
- Activating transcription factor 2,[5]
- Androgen receptor,[6]
- CREB-binding protein,[7][8]
- DNA-PKcs,[9]
- E2F1,[10]
- EP300,[9]
- Estrogen receptor alpha,[7][11]
- Estrogen receptor beta,[8][11]
- HBXIP,[12]
- HIST2H3C,[4]
- HSF1,[13]
- Ku70,[9][14]
- Ku80,[9][14]
- Liver X receptor beta,[8]
- MLL3,[4]
- RBBP5,[4]
- Retinoblastoma protein,[6]
- Retinoic acid receptor alpha,[7][8][9]
- Retinoid X receptor alpha,[7][8][11][12]
- Src,[4][7][8][15]
- TGS1,[16][17]
- TUBA4A,[4]
- TUBB,[4]
- Thyroid hormone receptor alpha,[7][15] and
- Thyroid hormone receptor beta.[7][8][9][11]
See also
References
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Further reading
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External links
- NCOA6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C94
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
