Metisazone
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(Redirected from Methisazone)
Names | |
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IUPAC name
[(1-Methyl-2-oxoindol-3-ylidene)amino]thiourea
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Other names
Metisazone
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Identifiers | |
1910-68-5 | |
ChEMBL | ChEMBL1512080 |
ChemSpider | 5259074 |
EC Number | 217-616-2 |
Jmol 3D model | Interactive image |
KEGG | D02496 |
MeSH | D008720 |
PubChem | 6861563 |
UNII | K3QML4J07E |
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Properties | |
C10H10N4OS | |
Molar mass | 234.28 g/mol |
Pharmacology | |
ATC code | J05 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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verify (what is ?) | |
Infobox references | |
Methisazone (USAN) or metisazone (INN) is an antiviral drug that works by inhibiting mRNA and protein synthesis, especially in pox viruses. It has been used in the past to treat smallpox.[1]
Methisazone has been described as being used in prophylaxis since at least 1965.[2][3]
Synthesis
When isatin is treated with NaH and MeI, the acidic hydrogen is alkylated to product 2. Then, reaction of the ketone carbonyl with thiosemicarbazine (3) leads to methisazone (4).
References
- ↑ Methisazone, Merriam-Webster's Medical Dictionary
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