Thymidine kinase from herpesvirus
From Infogalactic: the planetary knowledge core
| Thymidine kinase from herpesvirus | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:PDB 1kim EBI.jpg
Structure of thymidine kinase from herpesvirus.[1]
|
|||||||||
| Identifiers | |||||||||
| Symbol | Herpes_TK | ||||||||
| Pfam | PF00693 | ||||||||
| InterPro | IPR001889 | ||||||||
| SCOP | 1kin | ||||||||
| SUPERFAMILY | 1kin | ||||||||
|
|||||||||
Thymidine kinase from herpesvirus is a sub-family of thymidine kinases.[2]
Its presence in herpesvirus-infected cells is used to activate a range of antivirals against herpes infection, and thus specifically target the therapy towards infected cells only.
Such antivirals include:
- Purine analogues of guanine: Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir
- Vidarabine
- Pyrimidine analogues of uridine: Idoxuridine, Trifluridine
- Brivudine
Mutations in the gene coding thymidine kinase in herpes viruses can endow the virus with resistance to aciclovir. In these situations, alternative medications that are of use include other guanine analogues such as famciclovir, valaciclovir and penciclovir.
References
<templatestyles src="Asbox/styles.css"></templatestyles>
 |
This protein-related article is a stub. You can help Wikipedia by expanding it. |
