Pulmonary surfactant-associated protein C

Surfactant protein C
250px PDB rendering based on 1spf.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2YAD
Identifiers
Symbols	SFTPC ; BRICD6; PSP-C; SFTP2; SMDP2; SP-C
External IDs	OMIM: 178620 MGI: 109517 HomoloGene: 2271 GeneCards: SFTPC Gene
Gene ontology Molecular function • protein binding • protein homodimerization activity Cellular component • extracellular space • multivesicular body • alveolar lamellar body Biological process • respiratory gaseous exchange • circadian rhythm • response to glucose • response to lipopolysaccharide • response to retinoic acid • response to vitamin A • protein homooligomerization • response to glucocorticoid • response to cAMP • response to hyperoxia • response to interleukin-6 • response to growth factor • cellular response to mechanical stimulus • cellular response to nitric oxide Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SFTPC 38691 s at tn.png
File:PBB GE SFTPC 205982 x at tn.png
File:PBB GE SFTPC 211735 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6440	20389
Ensembl	ENSG00000168484	ENSMUSG00000022097
UniProt	P11686	Q6P8P8
RefSeq (mRNA)	NM_001172357	NM_011359
RefSeq (protein)	NP_001165828	NP_035489
Location (UCSC)	Chr 8: 22.16 – 22.16 Mb	Chr 14: 70.52 – 70.52 Mb
PubMed search	[1]	[2]

Pulmonary surfactant-associated protein C is a protein that in humans is encoded by the SFTPC gene.

It is a membrane protein which manufactures surfactant.

Clinical significance

It is associated with Surfactant metabolism dysfunction type 2.

Humans and animals born lacking SP-C tend to develop progressive interstitial pneumonitis.

See also

• Pulmonary_surfactant#Proteins

External links

• GeneReviews/NIH/NCBI/UW entry on Pulmonary Fibrosis, Familial
• Pulmonary Surfactant-Associated Protein B at the US National Library of Medicine Medical Subject Headings (MeSH)