LDL-receptor-related protein-associated protein

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Alpha-2-MRAP_N
	haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1.
Identifiers
Symbol	Alpha-2-MRAP_N
Pfam	PF06400
InterPro	IPR009066
SCOP	1lre
SUPERFAMILY	1lre
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Low density lipoprotein receptor-related protein associated protein 1
Low density lipoprotein receptor-related protein associated protein 1
	PDB rendering based on 1lre.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1LRE, 1NRE, 1OP1, 1OV2, 2FCW, 2FTU, 2FYL, 2P01, 2P03
Identifiers
Symbols	LRPAP1 ; A2MRAP; A2RAP; HBP44; MRAP; MYP23; RAP; alpha-2-MRAP
External IDs	OMIM: 104225 MGI: 96829 HomoloGene: 37612 GeneCards: LRPAP1 Gene
Gene ontology
Molecular function	• asialoglycoprotein receptor activity; • protein binding; • heparin binding; • lipase binding; • receptor antagonist activity; • low-density lipoprotein particle receptor binding; • unfolded protein binding; • very-low-density lipoprotein particle receptor binding;
Cellular component	• extracellular region; • endoplasmic reticulum; • plasma membrane; • cell surface; • integral component of membrane; • vesicle; • rough endoplasmic reticulum lumen;
Biological process	• protein folding; • receptor-mediated endocytosis; • negative regulation of very-low-density lipoprotein particle clearance; • vesicle-mediated transport; • negative regulation of protein binding; • extracellular negative regulation of signal transduction; • negative regulation of beta-amyloid clearance;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
Species	Human
Entrez	4043
Ensembl	ENSG00000163956
UniProt	P30533
RefSeq (mRNA)	NM_002337
RefSeq (protein)	NP_002328
Location (UCSC)	Chr 4:; 3.51 – 3.53 Mb
PubMed search	[1]
	v; t; e;

Alpha-2-MRAP_C

solution structure of domain 3 of rap

Identifiers

Symbol

Alpha-2-MRAP_C

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Low density lipoprotein receptor-related protein-associated protein 1 also known as LRPAP1 or RAP is a chaperone protein which in humans is encoded by the LRPAP1 gene.^[1]^[2]

Function

LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2.^[3] It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all known ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone.^[4] It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.