100,000 Genomes Project
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The 100,000 Genomes Project is a UK Government project which involves citizens and National Health Service information to perform whole genome sequencing of 100,000 participant samples by March 2018. The 100,000 Genomes Project is focusing on rare diseases, some common types of cancer, and infectious diseases.[1][2][3]
History
The project was first announced by UK Prime Minister David Cameron in December 2012.[4] The Government set up a new company Genomics England to oversee the project [3] with the plan to focus on rare diseases, cancer and infectious diseases announced by Health Secretary Jeremy Hunt in July 2013.
The initial participants were recruited from Cambridge University Hospitals, University College London Partners and Newcastle upon Tyne NHS Foundation Trust. The following medical centres joined the project a short time later: Central Manchester University Hospitals NHS Foundation Trust, Great Ormond Street Hospital, Guy's and St Thomas' NHS Foundation Trust, Moorfields Eye Hospital NHS Foundation Trust and Oxford University Hospitals NHS Trust.
As of December 2015, the 100,000 Genomes Project had already completed the sequencing of 6,000 whole genomes [5] as result, in 2016, a child with debilitating "mystery" diseases have finally been given a diagnosis.[6]
NHS Genomic Medicine Centres
Following the pilot studies, Genomics England ran a tender to appoint NHS Genomic Medicine Centres with responsibility for recruiting suitable patients, gaining their consent to participate in the project and taking samples for whole genome sequencing by Illumina (company). The successful bidders designated as NHS Genomic Medicine Centres are:
- East of England NHS GMC – designated for both cancer and rare disease. Led by Cambridge University Hospitals NHS Foundation Trust
- South London NHS GMC – designated for both cancer and rare disease. Led by Guy's and St Thomas' NHS Foundation Trust
- North West Coast NHS GMC – designated for both cancer and rare disease. Led by Liverpool Women's NHS Foundation Trust
- Greater Manchester NHS GMC – designated for both cancer and rare disease. Led by Central Manchester University Hospitals NHS Foundation Trust
- University College London Partners NHS GMC – designated for both cancer and rare disease. Led by Great Ormond Street Hospital for Children NHS Foundation Trust
- North East and North Cumbria NHS GMC – designated GMC for rare disease only. Led by The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Oxford NHS GMC – designated for both cancer and rare disease. Led by Oxford University Hospitals NHS Trust
- South West Peninsula NHS GMC – designated for both cancer and rare disease. Led by Royal Devon and Exeter NHS Foundation Trust
- Wessex NHS GMC – designated for both cancer and rare disease. Led by University Hospital Southampton NHS Foundation Trust
- Imperial College Health Partners NHS GMC – designated for both cancer and rare disease. Led by Imperial College Healthcare NHS Trust
- West Midlands NHS GMC – designated for both cancer and rare disease. Led by University Hospitals Birmingham NHS Foundation Trust
In December 2015, two new NHS Genomic Medicine Centres were announced by NHS England:[7]
- Yorkshire and Humber NHS GMC - designated for both cancer and rare disease.
- West of England NHS GMC - designated for both cancer and rare disease.
There are now 13 designated Genomic Medicine Centres (GMCs) across the country.
See also
External links
- Genomics England
- NHS England - Genomics
- East of England NHS Genomic Medicine Centre
- North Thames NHS Genomic Medicine Centre
References
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- ↑ First children diagnosed in DNA project by James Gallagher published by BBC News on January 12, 2016
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