Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Aldo-keto reductase family 1, member B1 (aldose reductase), also known as AR, is an enzyme that in humans is encoded by the AKR1B1 gene.[1][2]
Function
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.[2]
Gene
There are a few putative pseudogenes for this gene, and one of them has been confirmed and mapped to chromosome 3.[2]
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 2.0 2.1 2.2 Lua error in package.lua at line 80: module 'strict' not found.
Further reading
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PDB gallery
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1abn: THE CRYSTAL STRUCTURE OF THE ALDOSE REDUCTASE NADPH BINARY COMPLEX
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1ads: AN UNLIKELY SUGAR SUBSTRATE SITE IN THE 1.65 ANGSTROMS STRUCTURE OF THE HUMAN ALDOSE REDUCTASE HOLOENZYME IMPLICATED IN DIABETIC COMPLICATIONS
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1az1: ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
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1az2: CITRATE BOUND, C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
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1ef3: FIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE
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1el3: HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
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1iei: CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE INHIBITOR ZENARESTAT.
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1mar: REFINED 1.8 ANGSTROMS STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE POTENT INHIBITOR ZOPOLRESTAT
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1pwl: Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat
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1pwm: Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat
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1t40: Crystal structure of human aldose reductase complexed with NADP and IDD552 at ph 5
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1t41: Crystal structure of human aldose reductase complexed with NADP and IDD552
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1us0: HUMAN ALDOSE REDUCTASE IN COMPLEX WITH NADP+ AND THE INHIBITOR IDD594 AT 0.66 ANGSTROM
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1x96: Crystal structure of Aldose Reductase with citrates bound in the active site
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1x97: Crystal structure of Aldose Reductase complexed with 2R4S (Stereoisomer of Fidarestat, 2S4S)
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1x98: Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S)
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1xgd: Apo R268A human aldose reductase
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1z3n: Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom
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1z89: Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor
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1z8a: Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor
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2acq: AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE
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2acr: AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE
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2acs: AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE
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2acu: TYROSINE-48 IS THE PROTON DONOR AND HISTIDINE-110 DIRECTS SUBSTRATE STEREOCHEMICAL SELECTIVITY IN THE REDUCTION REACTION OF HUMAN ALDOSE REDUCTASE: ENZYME KINETICS AND THE CRYSTAL STRUCTURE OF THE Y48H MUTANT ENZYME
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2agt: Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat
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2dux: Crystal structure of human Aldose Reductase complexed with zopolrestat after 3 days soaking (3days_soaked_1)
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2duz: Human Aldose Reductase complexed with inhibitor zopolrestat after 3 days soaking (3days_soaked_2)
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2dv0: Human Aldose Reductase complexed with zopolrestat after 6 days soaking(6days_soaked_2)
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2f2k: Aldose reductase tertiary complex with NADPH and DEG
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2fz8: Human Aldose reductase complexed with inhibitor zopolrestat at 1.48 A(1 day soaking).
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2fz9: Human Aldose Reductase complexed with inhibitor zopolrestat after six days soaking.
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2fzb: Human Aldose Reductase complexed with four tolrestat molecules at 1.5 A resolution.
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2fzd: Human aldose reductase complexed with tolrestat at 1.08 A resolution.
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2hv5: Human Aldose Reductase complexed with inhibitor zopolrestat after three days soaking (3days_soaked_3)
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2hvn: Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation after one day (1day_cocryst)
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2hvo: Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation (10days_cocryst)
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2i16: Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 15K
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2i17: Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 60K
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2ikg: Aldose reductase complexed with nitrophenyl-oxadiazol type inhibitor at 1.43 A
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2ikh: Human aldose reductase complexed with nitrofuryl-oxadiazol inhibitor at 1.55 A
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2iki: Human aldose reductase complexed with halogenated IDD-type inhibitor
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2ikj: Human aldose reductase complexed with nitro-substituted IDD-type inhibitor
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2ine: Crystal Structure of Aldose Reductase complexed with Phenylacetic Acid
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2inz: Crystal Structure of Aldose Reductase complexed with 2-Hydroxyphenylacetic Acid
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2ipw: Crystal Structure of C298A W219Y Aldose Reductase complexed with Dichlorophenylacetic acid
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2iq0: Crystal Structure of Aldose Reductase complexed with Hexanoic Acid
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2iqd: Crystal Structure of Aldose Reductase complexed with Lipoic Acid
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2is7: Crystal Structure of Aldose Reductase complexed with Dichlorophenylacetic acid
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2isf: Crystal Structure of C298A W219Y Aldose Reductase complexed with Phenylacetic Acid
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2j8t: HUMAN ALDOSE REDUCTASE IN COMPLEX WITH NADP AND CITRATE AT 0.82 ANGSTROM
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2nvc: Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (3)
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2nvd: Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (2)
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2pev: Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594.
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2pf8: Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is equal to concentration of IDD594.
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2pfh: Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594.
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![2nvc: Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (3)](/w/index.php?title=Special:Upload&wpDestFile=PDB_2nvc_EBI.jpg){kind=link}
![2nvd: Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (2)](/w/index.php?title=Special:Upload&wpDestFile=PDB_2nvd_EBI.jpg){kind=link}
