Avibactam
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Systematic (IUPAC) name | |
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[(2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
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Clinical data | |
Trade names | Avycaz (formulated with ceftazidime) |
Pregnancy category |
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Legal status |
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Routes of administration |
IV |
Pharmacokinetic data | |
Bioavailability | 100% (intravenous) |
Protein binding | 5.7–8.2%[1] |
Metabolism | Nil |
Onset of action | Increases in proportion to dose |
Excretion | Renal (97%) |
Identifiers | |
CAS Number | 1192500-31-4 |
ATC code | None |
PubChem | CID: 9835049 |
ChemSpider | 8010770 |
KEGG | D10340 |
ChEBI | CHEBI:85984 |
ChEMBL | CHEMBL1689063 |
Chemical data | |
Formula | C7H11N3O6S |
Molecular mass | 265.24 g/mol |
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Avibactam is a non-β-lactam β-lactamase inhibitor antibiotic developed by Actavis (now Allergan) jointly with AstraZeneca. A new drug application for avibactam in combination with ceftazidime was approved by the FDA on February 25, 2015, for treating complicated urinary tract (cUTI) and complicated intra-abdominal infections (cIAI) caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant Gram-negative bacterial pathogens.[2][3][4]
Increasing resistance to cephalosporins among Gram-(−) bacterial pathogens, especially among hospital-acquired infections, results in part from the production of β-lactamase enzymes that deactivate these antibiotics. While the co-administration of a β-lactamase inhibitor can restore antibacterial activity to the cephalosporin, previously approved β-lactamase inhibitors such as tazobactam and clavulanic acid do not inhibit important classes of β-lactamases, including Klebsiella pneumoniae carbapenemases (KPCs), New Delhi metallo-β-lactamase 1 (NDM-1), and AmpC-type β-lactamases. Avibactam inhibits KPCs, AmpC, and some Class D β-lactamases, but is not active against NDM-1.[5]
References
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External links
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