BIN1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Myc box-dependent-interacting protein 1 is a protein that in humans is encoded by the BIN1 gene.[1][2][3]
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.[4]
Interactions
BIN1 has been shown to interact with Phospholipase D1,[5] SNX4[6] and PLD2.[5]
References
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Further reading
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This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |
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