Death-inducing signaling complex
From Infogalactic: the planetary knowledge core
Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors.[1] A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. The DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.
References
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External links
- DISC (Death Inducing Signaling Complex) at the US National Library of Medicine Medical Subject Headings (MeSH)
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