Douglas Fearon

Douglas Fearon
Born	Douglas Thomas Fearon (1942-10-16) October 16, 1942
Fields	Immunology
Alma mater	Williams College (BA 1964) Johns Hopkins Medical School (MD 1968)
Notable awards	FRS (1999) FRCP FMedSci
Website www.cruk.cam.ac.uk/research-groups/fearon-group

Douglas Thomas Fearon FRS FRCP FMedSci (born 16 October 1942) is an American medical immunologist, who has been since 2003 Sheila Joan Smith Professor of Immunology at the University of Cambridge and a fellow of Trinity College, Cambridge.

Awards and honours

Fearon was elected a Fellow of the Royal Society (FRS) in 1999 and is also member of the United States National Academy of Sciences. His nomination for the Royal Society reads:

The research of Douglas T. Fearon has helped establish a unifying principle in immunology; namely, that the two systems of immunity, innate and acquired, are integrated. The former identifies antigens of microbial origin to bias the response of the latter to those antigens. The support this thesis, he has 1) determined how the alternative complement pathway of innate immunity attaches C3 to microbial antigens; 2) demonstrated that the attached C3 causes antigen to be orders of magnitude more potent in eliciting an acquired immune response; and 3) characterised the CR2/CD19 receptor complex of B lymphocytes that mediates the enhanced immunogenicity of C3-bearing antigens, and the counter-regulatory coreceptor, CD22, that suppresses the cellular response to antigen.