Gemeprost
From Infogalactic: the planetary knowledge core
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Systematic (IUPAC) name | |
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methyl (2E,11α,13E,15R)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-2,13-dien-1-oate
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Clinical data | |
AHFS/Drugs.com | International Drug Names |
Routes of administration |
Pessary |
Identifiers | |
CAS Number | 64318-79-2 ![]() |
ATC code | G02AD03 (WHO) |
PubChem | CID: 5282237 |
DrugBank | DB08964 ![]() |
ChemSpider | 4445416 ![]() |
UNII | 45KZB1FOLS ![]() |
KEGG | D02073 ![]() |
Synonyms | methyl (E)-7-[(1R,2S,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-4,4-dimethyl-oct-1-enyl]-5-oxo-cyclopentyl]hept-2-enoate |
Chemical data | |
Formula | C23H38O5 |
Molecular mass | 394.545 g/mol |
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Gemeprost (16, 16-dimethyl-trans-delta2 PGE1 methyl ester) is an analogue of prostaglandin E1.
Clinical use
It is used as a treatment for obstetric bleeding.
It is used with mifepristone to terminate pregnancy up to 24 weeks gestation. [1]
Side effects
Vaginal bleeding, cramps, nausea, vomiting, loose stools or diarrhea, headache, muscle weakness; dizziness; flushing; chills; backache; dyspnoea; chest pain; palpitations and mild pyrexia. Rare: Uterine rupture, severe hypotension, coronary spasms with subsequent myocardial infarctions.
References
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