Interleukin-7 receptor
| Interleukin-7 receptor-α | |
|---|---|
| Identifiers | |
| Symbol | IL7R |
| Alt. symbols | CD127 |
| Entrez | 3575 |
| HUGO | 6024 |
| OMIM | 146661 |
| RefSeq | NM_002185 |
| UniProt | P16871 |
| Other data | |
| Locus | Chr. 5 p13 |
| interleukin 2 receptor, gamma | |
|---|---|
 |
|
| Identifiers | |
| Symbol | IL2RG |
| Alt. symbols | SCIDX1, IMD4, CD132 |
| Entrez | 3561 |
| HUGO | 6010 |
| OMIM | 308380 |
| RefSeq | NM_000206 |
| UniProt | P31785 |
| Other data | |
| Locus | Chr. X q13 |
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).[1][2] The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15.[3] Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.
Function
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination[citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation[citation needed]. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).[4]
Diseases
Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia,[5] multiple sclerosis,[6] rheumatoid arthritis and juvenile idiopathic arthritis.[7]
See also
References
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External links
- IL7R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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