Albinterferon
| Identifiers | |
|---|---|
| CAS Number | 472960-22-8 |
| ATC code | L03AB12 (WHO) (albinterferon alfa-2b) |
| Chemical data | |
| Formula | C3796H5937N1015O1143S50 |
| Molecular mass | 85.7 kg/mol |
Albinterferon (alb-IFN, trade name Albuferon) is a recombinant fusion protein drug consisting of interferon alpha (IFN-α) linked to human albumin.[1][2] Conjugation to human albumin prolongs the half-life of the IFN-α to about 6 days, allowing to dose it every two to four weeks.[3]
The drug was under investigation as an alternative to pegylated IFN-α-2a for the treatment of hepatitis C. In response to an FDA ruling, Novartis and Human Genome Sciences announced on October 5, 2010 that they will cease development of the drug.[4]
A French expert in hepatitis treatment, Dr. Yves Benhamou, member of the steering committee for a clinical trial of the drug was detained on criminal fraud charges by the F.B.I. agents on 11-01-2010 as he attended a conference in Boston because he allegedly tipped off a hedge fund manager about setbacks in the clinical trials (two participants in the trial had developed lung disease and one of them died); he had a consulting relationship with a manager of the hedge fund. The manager sold his entire stake in Human Genome Sciences before it announced the setbacks in Jan. 2008 and avoided $30 million in losses.[5][6]
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Statement on a nonproprietary name adopted by the USAN Council
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://www.google.com/hostednews/ap/article/ALeqM5h_xwTjacvhKutLYGE0w6FEuuaEQwD9ILM7MG1?docId=D9ILM7MG1
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://newyork.fbi.gov/dojpressrel/pressrel10/nyfo110210a.htm
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