Small nucleolar RNA SNORA74
From Infogalactic: the planetary knowledge core
| Small nucleolar RNA SNORA74 | |
|---|---|
| 220px | |
| Predicted secondary structure and sequence conservation of SNORA74 | |
| Identifiers | |
| Symbol | SNORA74 |
| Alt. Symbols | U19 |
| Rfam | RF00090 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; H/ACA-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000594 |
Small nucleolar RNA SNORA74 (U19) belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs.[1] Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNase MRP RNA suggests that U19 may be involved in pre-rRNA processing.[2][3]
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