Trypanosomiasis vaccine
A Trypanosomiasis vaccine is a vaccine against trypanosomiasis. No effective vaccine currently exists, but development of a vaccine is the subject of current research. The Bill & Melinda Gates Foundation has been involved in funding research.[1]
There are many obstacles to development of such a vaccine. One obstacle is variant surface glycoprotein which makes it difficult for the immune system to recognize the infectious organism.[2]
Also, Trypanosoma brucei has a direct inhibitory effect upon B cells.[3]
One strategy may involve a vaccine against the initial antigens.[4]
It has been suggested that it may be more productive to generate an immune response against the cysteine protease (for example, cruzipain), rather than the organism itself.[5][6]
There are two known subspecies that infect humans, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense.
See also
References
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