ADX-47273

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ADX-47273
ADX-47273 structure.png
Systematic (IUPAC) name
(S)-(4-fluorophenyl)-(3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]piperidin-1-yl)methanone
Identifiers
CAS Number 851881-60-2 YesY
851881-59-9 (R isomer),
837413-22-6 (racemate)
PubChem CID: 11383075
IUPHAR/BPS 1420
ChemSpider 9557988 YesY
ChEMBL CHEMBL381055 YesY
Chemical data
Formula C20H17F2N3O2
Molecular mass 369.364 g/mol
  • FC1=CC=C(C(N2CCC[C@@H](C2)C3=NC(C4=CC=C(F)C=C4)=NO3)=O)C=C1
  • InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1 YesY
  • Key:VXQCCZHCFBHTTD-HNNXBMFYSA-N YesY
  (verify)

ADX-47273 is a research pharmaceutical developed by Addex Therapeutics which acts as a positive allosteric modulator (PAM) selective for the metabotropic glutamate receptor subtype mGluR5.[1][2] It has nootropic and antipsychotic effects in animal studies,[3] and has been used as a lead compound to develop improved derivatives.[4]

See also

References

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  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.



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