Metaphit
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Names | |
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IUPAC name
1-[1-(3-isothiocyanatophenyl)cyclohexyl]piperidine
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Identifiers | |
ChEMBL | ChEMBL41541 Y |
ChemSpider | 102730 Y |
Jmol 3D model | Interactive image |
PubChem | 114745 |
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Properties | |
C18H24N2S | |
Molar mass | 300.462 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Y verify (what is YN ?) | |
Infobox references | |
Metaphit (1-[1-(3-Isothiocyanato)phenyl]cyclohexylpiperidine) is a research chemical that acts as an acylator of NMDARAn, sigma and DAT binding sites in the CNS. It is the m-isothiocyanate derivative of phencyclidine & binds irreversibly (forming a covalent bond) to the PCP binding site on the NMDA receptor complex.[1] However, later studies suggest the functionality of metaphit is mediated by sites not involved in PCP-induced passive avoidance deficit, and not related to the NMDA receptor complex.[2] Metaphit was also shown to prevent d-amphetamine induced hyperactivity, while significantly depleting dopamine content in the nucleus accumbens.[3] Metaphit was the first acylating ligand used to study the cocaine receptor.[4]
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Categories:
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- Articles without KEGG source
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- Dopamine reuptake inhibitors
- Dissociative drugs
- NMDA receptor antagonists
- Piperidines
- Sigma agonists
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