GPR128
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene.[1][2][3] GPR128 is a member of the adhesion GPCR family.[4][5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6]
GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.[7]
Function
Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.[8]
Clinical significance
A 111-kb amplification with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.[9] Notably, the fused gene was also detected in few healthy individuals.
References
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