Monocarboxylate transporter 1

Solute carrier family 16 (monocarboxylate transporter), member 1
Identifiers
Symbols	SLC16A1 ; HHF7; MCT; MCT1; MCT1D
External IDs	OMIM: 600682 MGI: 106013 HomoloGene: 20662 ChEMBL: 4360 GeneCards: SLC16A1 Gene
Gene ontology Molecular function • monocarboxylic acid transmembrane transporter activity • lactate transmembrane transporter activity • mevalonate transmembrane transporter activity • symporter activity • protein homodimerization activity • organic cyclic compound binding Cellular component • mitochondrion • centrosome • plasma membrane • integral component of plasma membrane • membrane • integral component of membrane • extracellular exosome Biological process • pyruvate metabolic process • lipid metabolic process • blood coagulation • monocarboxylic acid transport • mevalonate transport • response to food • plasma membrane lactate transport • glucose homeostasis • cellular metabolic process • small molecule metabolic process • regulation of insulin secretion • leukocyte migration • centrosome organization • behavioral response to nutrient • transmembrane transport • cellular response to organic cyclic compound Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6566	20501
Ensembl	ENSG00000155380	ENSMUSG00000032902
UniProt	P53985	P53986
RefSeq (mRNA)	NM_001166496	NM_009196
RefSeq (protein)	NP_001159968	NP_033222
Location (UCSC)	Chr 1: 112.91 – 112.96 Mb	Chr 3: 104.64 – 104.66 Mb
PubMed search	[1]	[2]

Monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC16A1 gene (also known as MCT1). It is a proton coupled monocarboxylate transporter.

Detailed kinetic analysis of monocarboxylate transport in erythrocytes revealed that MCT1 operates through an ordered mechanism. MCT1 has a substrate binding site open to the extracellular matrix which binds a proton first followed by the lactate anion. The protein then undergoes a conformational change to a new ‘closed’’ conformation that exposes both the proton and lactate to the opposite surface of the membrane where they are released, lactate first and then the proton. For net transport of lactic acid, the rate-limiting step is the return of MCT1 without bound substrate to the open conformation. For this reason, exchange of one monocarboxylate inside the cell with another outside is considerably faster than net transport of a monocarboxylate across the membrane.

See also

• Monocarboxylate transporter