SLC4A5

Solute carrier family 4 (sodium bicarbonate cotransporter), member 5
Identifiers
Symbols	SLC4A5 ; NBC4
External IDs	OMIM: 606757 MGI: 2443220 HomoloGene: 31125 GeneCards: SLC4A5 Gene
Gene ontology Molecular function • inorganic anion exchanger activity • sodium:bicarbonate symporter activity Cellular component • plasma membrane • integral component of plasma membrane • integral component of membrane • apical plasma membrane Biological process • epithelial cell development • renal system process • regulation of systemic arterial blood pressure • ion transport • regulation of gene expression • bicarbonate transport • cerebrospinal fluid secretion • sodium ion transmembrane transport • mitochondrion distribution • regulation of intracellular pH • transmembrane transport • retina development in camera-type eye • anion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SLC4A5 221723 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57835	232156
Ensembl	ENSG00000188687	ENSMUSG00000068323
UniProt	Q9BY07	D3YVG0
RefSeq (mRNA)	NM_021196	NM_001166067
RefSeq (protein)	NP_067019	NP_001159539
Location (UCSC)	Chr 2: 74.22 – 74.34 Mb	Chr 6: 83.22 – 83.3 Mb
PubMed search	[1]	[2]

Electrogenic sodium bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene.

Function

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Clinical significance

This human gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status.

See also

• SLC4A5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.