SLC46A1

Solute carrier family 46 (folate transporter), member 1
Identifiers
Symbols	SLC46A1 ; G21; HCP1; PCFT
External IDs	OMIM: 611672 MGI: 1098733 HomoloGene: 41693 ChEMBL: 1795188 GeneCards: SLC46A1 Gene
Gene ontology Molecular function • folic acid binding • folic acid transporter activity • hydrogen ion transmembrane transporter activity • heme transporter activity • methotrexate transporter activity Cellular component • cytoplasm • plasma membrane • cell surface • integral component of membrane • apical plasma membrane • brush border membrane Biological process • vitamin metabolic process • water-soluble vitamin metabolic process • cellular iron ion homeostasis • folic acid transport • heme transport • small molecule metabolic process • folic acid metabolic process • methotrexate transport • transmembrane transport • hydrogen ion transmembrane transport • folic acid import into cell Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PCFT gnf1h08403 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	113235	52466
Ensembl	ENSG00000076351	ENSMUSG00000020829
UniProt	Q96NT5	Q6PEM8
RefSeq (mRNA)	NM_001242366	NM_026740
RefSeq (protein)	NP_001229295	NP_081016
Location (UCSC)	Chr 17: 28.39 – 28.41 Mb	Chr 11: 78.47 – 78.47 Mb
PubMed search	[1]	[2]

Solute carrier family 46 (folate transporter), member 1 (SLC46A1) also known as proton-coupled folate transporter (PCFT), is a protein which in humans is encoded by the SLC46A1 gene.

Function

SLC46A1 is responsible for the intestinal uptake of folate.

External links

• GeneReview/NIH/UW entry on Hereditary Folate Malabsorption