Benzhydryl compounds
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File:Benzhydryl.png
Chemical structure of the benzhydryl radical
File:Benzhydryl2.png
Ball-and-stick model of benzhydryl group
Benzhydryl compounds are compounds that are "diphenylmethane"-containing, i.e. two benzene rings adjoining a single carbon. This simple definition does not include heteroaromatic ring moieties, which would complicate the situation even further. Although it may still be desired to include these for the purposes of 'completeness' they ought to be kept separate to avoid confusion.[who?]
Contents
Carboaromatic
Alcohols
- Acyclic: pridinol
- Pyrolidino: diphenylprolinol
- 2-Piperidine: pipradrol
- 4-Piperidine: terfenadine, fexofenadine
- Benzilic ester: QNB, JB-336, JB-318, benactyzine
Alkenes
- Tricycle: amitriptyline, melitracen, cyclobenzaprine, tianeptine, amineptine, clopenthixol chlorprothixene flupentixol thiothixene zuclopenthixol
- Tricyclic and piperidine: pimethixene, cyproheptadine
- Acyclic: gilutensin
Alkyl(amine)s
- Acyclic: (3-phenylpropylamine), tolpropamine, tolterodine
- Piperidine: desoxypipradrol, budipine[1]
- N-alkyl-4-piperidinol: penfluridol
- N-arylalkyl-piperidine: pimozide
- Tetrahydronaphthalene: tametraline (4-phenylaminotetralin), sertraline
- Tetrahydroisoquinoline: nomifensine, diclofensine "tetrahydronaphisoquinoline", dinapsoline (c.f. doxanthrine and dinoxyline)
- Pyrroloisoquinoline: JNJ-7925476
- Indanamine: Lu 19-005
- Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene, phenindamine (see MPTP)
- Tetracyclic: maprotiline, dihydrexidine, butaclamol, ecopipam
- Tetrahydrobenzazepine: SKF-83959, SKF-82958, SKF-81297, SKF 38393, fenoldopam, 6-Br-APB, SCH 23390
- Piperazine: amperozide
- Triazaspiro: fluspirilene
Alkoxy compounds
- Acyclic (3°C): diphenhydramine (c.f deramciclane), orphenadrine, p-methyldiphenhydramine
- Acyclic (4°C): moxastine, Clemastine, embramine,
- Piperazine: GBR-12935, GBR 12909, DBL-583
- Tropine: benztropine, deptropine, etybenzatropine, difluoropine
- Piperidine: diphenylpyraline
- Phthalane: talopram, citalopram
- Octahedral: nefopam
- Benzdihydropyran: A-68930 (isochromene)
Amines
- Piperazine: cyclizine, clocinizine, hydroxyzine, meclozine, cetirizine dotarizine, cinnarizine.
- Benzazepine: mianserin
- Tetracyclic: dizocilpine
Other
- Aromatic alkoxy: bifemelane, phenyltoloxamine
- Keto: phenadoxone, methadone, dipipanone, etc.
- Amido: dextromoramide
- Imino: benzodiazepine, GYKI-52895
- Sulfinyl: modafinil, adrafinil
- Pituxate gem-diphenylcyclopropane
Hetereoaromatic
Heteroaromatic rings
- Alkene: thiambutene, loratidine
- Alkylamine: A-86929, amfonelic acid
Benzenes linked by a non-carbon atom
- Nitrogen: promethazine, imipramine, acepromazine, chlorpromazine, fluphenazine, mesoridazine, levomepromazine, perazine, periciazine, perphenazine, prochlorperazine, sulforidazine, thioridazine, trifluoperazine, triflupromazine, clozapine, thiethylperazine
- Indolic nitrogen: sertindole
- Oxygen: loxapine, asenapine, tyrima
Benzene and heterocycle linked through a non-carbon
References
External links
- Benzhydryl Compounds at the US National Library of Medicine Medical Subject Headings (MeSH)
- PubChem - Benzhydryl bromideth:ไดฟีนิลไพราลีน
