UDP-glucose 6-dehydrogenase

UDP-glucose 6-dehydrogenase
250px Rendering based on PDB 2Q3E.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2Q3E, 2QG4, 3ITK, 3KHU, 3PRJ, 3PTZ, 3TDK, 3TF5, 4EDF, 4QEJ, 4RJT
Identifiers
Symbols	UGDH ; GDH; UDP-GlcDH; UDPGDH; UGD
External IDs	OMIM: 603370 MGI: 1306785 HomoloGene: 2520 GeneCards: UGDH Gene
EC number	1.1.1.22
Gene ontology Molecular function • UDP-glucose 6-dehydrogenase activity • electron carrier activity • NAD binding Cellular component • nucleoplasm • cytosol • extracellular exosome Biological process • carbohydrate metabolic process • UDP-glucose metabolic process • glycosaminoglycan biosynthetic process • UDP-glucuronate biosynthetic process • xenobiotic metabolic process • small molecule metabolic process • cellular glucuronidation • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE UGDH 203343 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7358	22235
Ensembl	ENSG00000109814	ENSMUSG00000029201
UniProt	O60701	O70475
RefSeq (mRNA)	NM_001184700	NM_009466
RefSeq (protein)	NP_001171629	NP_033492
Location (UCSC)	Chr 4: 39.5 – 39.53 Mb	Chr 5: 65.41 – 65.44 Mb
PubMed search	[1]	[2]

UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene.

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.

This enzyme participates in 4 metabolic pathways: pentose and glucuronate interconversions, ascorbate and aldarate metabolism, starch and sucrose metabolism, and nucleotide sugars metabolism.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is UDP-glucose:NAD⁺ 6-oxidoreductase.

Other names in common use include:

• UDP-glucose dehydrogenase,
• uridine diphosphoglucose dehydrogenase,
• UDPG dehydrogenase,
• UDPG:NAD oxidoreductase,
• UDP-alpha-D-glucose:NAD oxidoreductase,
• UDP-glucose:NAD⁺ oxidoreductase,
• uridine diphosphate glucose dehydrogenase,
• UDP-D-glucose dehydrogenase, and
• uridine diphosphate D-glucose dehydrogenase.

Biochemistry

UDP-glucose 6-dehydrogenase
Identifiers
EC number	1.1.1.22
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a UDP-glucose 6-dehydrogenase (EC 1.1.1.22) is an enzyme that catalyzes the chemical reaction

UDP-glucose + 2 NAD⁺ + H₂O $\rightleftharpoons$ UDP-glucuronate + 2 NADH + 2 H⁺

The 3 substrates of this enzyme are UDP-glucose, NAD⁺, and H₂O, whereas its 3 products are UDP-glucuronate, NADH, and H⁺

References: