CDK12

Cyclin-dependent kinase 12
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CXA, 4NST, 4UN0
Identifiers
Symbols	CDK12 ; CRK7; CRKR; CRKRS
External IDs	OMIM: 615514 MGI: 1098802 HomoloGene: 128632 GeneCards: CDK12 Gene
EC number	2.7.11.22, 2.7.11.23
Gene ontology Molecular function • protein kinase activity • cyclin-dependent protein serine/threonine kinase activity • protein binding • ATP binding • RNA polymerase II carboxy-terminal domain kinase activity • cyclin binding Cellular component • cyclin K-CDK12 complex • nucleus • nucleoplasm • nucleolus • nuclear speck • nuclear cyclin-dependent protein kinase holoenzyme complex Biological process • mRNA processing • RNA splicing • regulation of MAP kinase activity • regulation of RNA splicing • protein autophosphorylation • regulation of cell cycle • phosphorylation of RNA polymerase II C-terminal domain Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51755	69131
Ensembl	ENSG00000167258	ENSMUSG00000003119
UniProt	Q9NYV4	Q14AX6
RefSeq (mRNA)	NM_015083	NM_001109626
RefSeq (protein)	NP_055898	NP_001103096
Location (UCSC)	Chr 17: 39.46 – 39.56 Mb	Chr 11: 98.2 – 98.28 Mb
PubMed search	[1]	[2]

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of cyclin-dependent kinase protein family.