NUAK1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.[1][2][3]
Contents
Function
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Clinical significance
ARK5 is important in tumor malignancy and invasiveness.[4]
Research findings
ARK5 is often overexpressed in multiple myeloma cell lines.[5][6] ARK5 promotes tumor cell survival under regulation by Akt.[4]
ARK5 increases MT1-MMP production.[4] (MT1-MMP activates MMP-2 and MMP-9 which are involved in tumor metastasis.[4])
As a drug target
ON123300 (a CDK4 inhibitor), also inhibits ARK5 and reduces proliferation of multiple myeloma and mantle cell lymphoma cell lines.[5]
Interactions
NUAK1 has been shown to interact with USP9X[7] and Ubiquitin C.[7]
References
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- ↑ 4.0 4.1 4.2 4.3 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 5.0 5.1 Multi-Target Drug Blocks Myeloma Proliferation. March 2016
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Further reading
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