MAPK3

Main article: Extracellular signal-regulated kinases

Mitogen-activated protein kinase 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ZOQ, 4QTB
Identifiers
Symbols	MAPK3 ; ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK
External IDs	OMIM: 601795 MGI: 1346859 HomoloGene: 55682 ChEMBL: 3385 GeneCards: MAPK3 Gene
EC number	2.7.11.24
Gene ontology Molecular function • phosphotyrosine binding • MAP kinase activity • protein binding • ATP binding • phosphatase binding • scaffold protein binding Cellular component • nucleus • nuclear envelope • nucleoplasm • mitochondrion • early endosome • late endosome • Golgi apparatus • cytosol • cytoskeleton • caveola • focal adhesion • microtubule cytoskeleton • pseudopodium • protein complex • extracellular exosome Biological process • MAPK cascade • activation of MAPKK activity • activation of MAPK activity • MAPK import into nucleus • positive regulation of protein phosphorylation • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • protein complex assembly • protein phosphorylation • apoptotic process • DNA damage induced protein phosphorylation • cell cycle • epidermal growth factor receptor signaling pathway • small GTPase mediated signal transduction • Ras protein signal transduction • axon guidance • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • response to toxic substance • gene expression • viral process • phosphorylation • peptidyl-serine phosphorylation • cytokine-mediated signaling pathway • sensory perception of pain • arachidonic acid metabolic process • platelet activation • BMP signaling pathway • positive regulation of cyclase activity • lipopolysaccharide-mediated signaling pathway • regulation of stress-activated MAPK cascade • positive regulation of histone phosphorylation • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • cellular response to heat • positive regulation of histone acetylation • TRIF-dependent toll-like receptor signaling pathway • peptidyl-tyrosine autophosphorylation • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • response to exogenous dsRNA • innate immune response • positive regulation of translation • positive regulation of transcription from RNA polymerase II promoter • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • regulation of sequence-specific DNA binding transcription factor activity • cartilage development • stress-activated MAPK cascade • regulation of cytoskeleton organization • JAK-STAT cascade involved in growth hormone signaling pathway • lung morphogenesis • trachea formation • ERK1 and ERK2 cascade • positive regulation of ERK1 and ERK2 cascade • interleukin-1-mediated signaling pathway • response to epidermal growth factor • cellular response to mechanical stimulus • caveolin-mediated endocytosis • regulation of Golgi inheritance • regulation of cellular response to heat • regulation of early endosome to late endosome transport • negative regulation of apolipoprotein binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5595	26417
Ensembl	ENSG00000102882	ENSMUSG00000063065
UniProt	P27361	Q63844
RefSeq (mRNA)	NM_001040056	NM_011952
RefSeq (protein)	NP_001035145	NP_036082
Location (UCSC)	Chr 16: 30.11 – 30.12 Mb	Chr 7: 126.76 – 126.77 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene.

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.

Clinical significance

It has been suggested that MAPK3, along with the gene IRAK1, is turned off by two microRNAs that were activated after the influenza A virus had been made to infect human lung cells.

Interactions

MAPK3 has been shown to interact with:

• DUSP3,
• DUSP6
• GTF2I,
• HDAC4,
• MAP2K1,
• MAP2K2,
• PTPN7,
• RPS6KA2, and
• SPIB.

External links

• MAP Kinase Resource .