Nepicastat
From Infogalactic: the planetary knowledge core
Names | |
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IUPAC name
5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1,3-dihydro-2H-imidazole-2-thione
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Other names
SYN-117
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Identifiers | |
173997-05-2 | |
ChemSpider | 7971947 |
6630 | |
Jmol 3D model | Interactive image |
MeSH | Nepicastat |
PubChem | 9796181 |
UNII | VPG12K4540 |
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Properties | |
C14H15F2N3S | |
Molar mass | 295.35 g/mol |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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verify (what is ?) | |
Infobox references | |
Nepicastat (INN, codenamed SYN117, RS-25560-197) is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.[1]
It has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such.[2] As of 2012, clinical trials to assess nepicastat as a treatment for post-traumatic stress disorder (PTSD) and cocaine dependence have been completed.[3][4] In Phase 2 study treatment with nepicastat was not effective in relieving PTSD-associated symptoms when compared to placebo. The study was funded by the U.S. Department of Defense.[5]
References
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- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found. Retrieved on February 1, 2012.
- ↑ Lua error in package.lua at line 80: module 'strict' not found. Retrieved on February 1, 2012.
- ↑ Biotie reports top-line data from clinical study with nepicastat (SYN117) in post-traumatic stress disorder BIOTIE THERAPIES CORP. STOCK EXCHANGE RELEASE 27 December 2012.
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Categories:
- Articles without EBI source
- Articles without KEGG source
- Pages using collapsible list with both background and text-align in titlestyle
- Chemical articles using a fixed chemical formula
- Imidazolines
- Fluoroarenes
- Tetralins
- Thioureas
- Dopamine beta hydroxylase inhibitors
- Cardiovascular system drug stubs
- Nervous system drug stubs