CD163
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene.[1] CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex and in the absence of haptoglobin - with lower affinity - for hemoglobin alone.[2] It has also been shown to mark cells of monocyte/macrophage lineage.[3]
The receptor was discovered in 1987.[4]
Contents
Structure
The molecular size is 130 kDa. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants.
Clinical significance
A soluble form of the receptor exists in plasma, commonly denoted sCD163. It is generated by ectodomain shedding of the membrane bound receptor. sCD163 is upregulated in a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.[5][6]
Interactions
CD163 has been shown to interact with CSNK2B.[7]
See also
References
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- ↑ CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash AI, Schaffner A. Blood. 2006 Jan 1;107(1):373-80. PMID 16189277
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Further reading
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External links
- CD163 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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