PKMYT1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1 gene.[1][2][3]
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Interactions
PKMYT1 has been shown to interact with PIN1[4] and STEAP3.[2]
References
Further reading
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