VRK2

Vaccinia related kinase 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2V62
Identifiers
Symbol	VRK2
External IDs	OMIM: 602169 MGI: 1917172 HomoloGene: 55966 ChEMBL: 1649059 GeneCards: VRK2 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase binding • protein domain specific binding Cellular component • nucleus • cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • integral component of membrane • mitochondrial membrane • protein complex Biological process • protein phosphorylation • endocytosis • regulation of cell shape • viral process • Wnt signaling pathway • peptidyl-serine phosphorylation • cellular response to oxidative stress • regulation of MAPK cascade • protein autophosphorylation • regulation of interleukin-1-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE VRK2 205126 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7444	69922
Ensembl	ENSG00000028116	ENSMUSG00000064090
UniProt	Q86Y07	Q8BN21
RefSeq (mRNA)	NM_001130480	NM_001252447
RefSeq (protein)	NP_001123952	NP_001239376
Location (UCSC)	Chr 2: 57.91 – 58.16 Mb	Chr 11: 26.47 – 26.59 Mb
PubMed search	[1]	[2]

Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene.

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. While several transcript variants may exist for this gene, the full-length nature of only one has been biologically validated to date.