Triphenylethylene

Triphenylethylene

File:Triphenylethylene.svg
Systematic (IUPAC) name
1,2-Diphenylethenylbenzene
Identifiers
CAS Number	58-72-0
PubChem	CID: 6025
ChemSpider	5803
Chemical data
Formula	C20H16
Molecular mass	256.34104 g/mol
SMILES C1=CC=C(C=C1)C=C(C2=CC=CC=C2)C3=CC=CC=C3
InChI InChI=1S/C20H16/c1-4-10-17(11-5-1)16-20(18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-16H Key:MKYQPGPNVYRMHI-UHFFFAOYSA-N

Triphenylethylene (TPE) is a simple aromatic hydrocarbon that possesses weak estrogenic properties.

TPE is the parent compound of a group of non-steroidal selective estrogen receptor modulators (SERMs) that includes tamoxifen, clomiphene, chlorotrianisene, DBE, broparestrol, toremifene, droloxifene, idoxifene, ospemifene, fispemifene, and miproxifene, among others.

TPE and its SERM derivatives were derived from structural modification of diethylstilbestrol.

See also

• Benzothiophene – parent compound for another group of non-steroidal SERMs that includes raloxifene
• Ethamoxytriphetol (MER-25) – a drug related to the TPEs and the first antiestrogen to be discovered
• Stilbestrol – parent compound of a group of non-steroidal estrogens that includes diethylstilbestrol
• Phenanthrene – parent compound of steroidal estrogens like estradiol
• Chrysene – parent compound of a group of non-steroidal weak estrogens that includes 2,8-DHHHC and tetrahydrochrysene
• Doisynolic acid – parent compound of a group of non-steroidal estrogens that includes doisynoestrol