DR-4485

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DR-4485
DR-4485 structure.png
Systematic (IUPAC) name
6-chloro-2a-(4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl)-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)one
Identifiers
CAS Number 402942-53-4 N
PubChem CID: 9911844
Chemical data
Formula C26H28Cl2N2O
Molecular mass 455.418 g/mol
  • c4cc(Cl)ccc4C(CC5)=CCN5CCCCC2(CCC3)c1c3c(Cl)ccc1NC2=O

DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT7 receptor, with good oral bioavailability. It has been used to research the function of this still comparatively little studied serotonin receptor subtype.[1][2]

References

  1. ↑ Kikuchi C, Suzuki H, Hiranuma T, Koyama M. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorganic and Medicinal Chemistry Letters. 2003 Jan 6;13(1):61-4. PMID 12467617
  2. ↑ Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2384-92. DOI 10.1021/jm8014553. PMID 19326916


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