Vorozole

Vorozole
	File:Vorozole.svg
Systematic (IUPAC) name
	6-[(4-Chlorophenyl)(1,2,4-triazol-1-yl)methyl]-1-methylbenzotriazole
Pharmacokinetic data
Bioavailability	Very high
Metabolism	Hepatic
Biological half-life	8 hours
Identifiers
CAS Number	118949-22-7
ATC code	L02BG05 (WHO)
PubChem	CID: 6918191
ChemSpider	5293402
UNII	1E2S9YXV2A
KEGG	D03786
ChEMBL	CHEMBL224060
Chemical data
Formula	C16H13ClN6
Molecular mass	324.768 g/mol
	SMILES Clc1ccc(cc1)[C@@H](c2ccc3nnn(c3c2)C)n4ncnc4 ;
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Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.

It is selective.^[1]

References

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