Distigmine
From Infogalactic: the planetary knowledge core
![]() Distigmine bromide
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Systematic (IUPAC) name | |
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(1-methylpyridin-1-ium-3-yl) N-methyl-N-{6-[methyl-
(1-methylpyridin-1-ium-3-yl)oxycarbonylamino] hexyl}carbamate dibromide |
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Clinical data | |
Routes of administration |
oral, i.m. |
Pharmacokinetic data | |
Bioavailability | 4.65 % [1] |
Biological half-life | 65 h [1] |
Excretion | renal [1] |
Identifiers | |
CAS Number | 15876-67-2 |
ATC code | N07AA03 (WHO) |
PubChem | CID: 27522 |
ChemSpider | 25613 ![]() |
UNII | T940307O7B ![]() |
KEGG | D01228 |
ChEMBL | CHEMBL1098285 ![]() |
Chemical data | |
Formula | C22H32Br2N4O4 |
Molecular mass | 576.322 g/mol |
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Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.
References
- ↑ 1.0 1.1 1.2 The Japanese Pharmacopoeia, Edition 14/I: Official Monographs, Yakuji Nippo. Ltd., Tokyo (2001), ISBN 978-4840806725, Page 599.
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