SL65.0155

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SL65.0155
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Systematic (IUPAC) name
5-(5-amino-6-chloro-2,3-dihydro-1,4-benzodioxin-8-yl)-3-(1-phenethyl-4-piperidyl)-1,3,4-oxadiazol-2-one hydrochloride
Identifiers
CAS Number ?
ATC code none
PubChem CID: 9805718
ChemSpider 7981478
Chemical data
Formula C23H26Cl2N4O4
Molecular mass 493.38 g/mol
  • Cl.O=C1O/C(=NN1C3CCN(CCc2ccccc2)CC3)c5cc(Cl)c(c4OCCOc45)N

SL65.0155 is a selective 5-HT4 receptor partial agonist (Ki = 0.6 nM; IA = 40-50% (relative to 5-HT)).[1] It potently enhances cognition, learning, and memory,[1][2][3][4][5][6] and also possesses antidepressant effects.[7] SL65.0155 was in phase II clinical trials around 2004-2006 for the treatment of memory deficits and dementia but no new information has surfaced since and it appears to have been abandoned.[8][9]

See also

References

  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
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  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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