Chlornaltrexamine

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Chlornaltrexamine
Chlornaltrexamine.svg
Names
IUPAC name
6-(Bis(2-chloroethyl)amino)-17-(cyclopropylmethyl)-4,5-epoxy-(5α,6β)-morphinan-3,14-diol
Other names
α-Chlornaltrexamine
Identifiers
67025-94-9 YesY
ChemSpider 4588895 N
Jmol 3D model Interactive image
PubChem 5486190
Properties
C24H32Cl2N2O3
Molar mass 467.43 g/mol
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Chlornaltrexamine is an irreversible mixed agonist–antagonist for μ-opioid receptors, which forms a covalent bond to the active site. It is twenty-two times more potent than morphine. Its alkylating group is a bis(chloroalkyl)amino-residue similar to that of the nitrogen mustards.[1] [2] [3] [4] [5][6]

See also

References

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  4. Caruso TP, Larson DL, Portoghese PS, Takemori AE (June 1980). "Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine". J. Pharmacol. Exp. Ther. 213 (3): 539–44. PMID 6162947.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
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