4-Nonylphenylboronic acid

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4-Nonylphenylboronic acid
4-Nonylphenylboronicacid structure.png
Systematic (IUPAC) name
4-Nonylphenylboronic acid
Identifiers
CAS Number 256383-45-6
ATC code None
PubChem CID: 4589192
ChemSpider 3781380
Chemical data
Formula C15H25BO2
Molecular mass 248.17 g/mol
  • OB(O)C1=CC=C(CCCCCCCCC)C=C1
  • InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
  • Key:VONVJOGSLHAKOX-UHFFFAOYSA-N

4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme MAGL, which it inhibits with an IC50 of 7900nM.[1] It is also a weaker inhibitor of the enzymes endothelial lipase and lipoprotein lipase, with IC50 values of 100nM and 1400nM respectively.[2]

See also

References

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  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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