N-Methylcarfentanil
200px | |
Systematic (IUPAC) name | |
---|---|
Methyl 1-methyl-4-(N-phenylpropionamido)piperidine-4-carboxylate
|
|
Clinical data | |
Pregnancy category |
|
Pharmacokinetic data | |
Bioavailability | ? |
Protein binding | ? |
Metabolism | ? |
Excretion | ? |
Identifiers | |
ChemSpider | 26231037 |
Chemical data | |
Formula | C17H24N2O3 |
Molecular mass | 304.384 g/mol |
|
|
|
|
(verify) |
N-Methylcarfentanil (R-32395) is an opioid analgesic drug related to the highly potent animal tranquilizer carfentanil, but several thousand times weaker, being only slightly stronger than morphine. It was first synthesised by a team of chemists at Janssen Pharmaceutica led by Paul Janssen, who were investigating the structure-activity relationships of the fentanyl family of drugs. They found that replacing the phenethyl group attached to the piperidine nitrogen of fentanyl with a smaller methyl group, made it so much weaker that it was inactive as an analgesic in animals. However the same change made to the more potent analogue carfentanil retained reasonable opioid receptor activity, reflecting the higher binding affinity produced by the 4-carbomethoxy group.[1][2][3]
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[4]
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Dukhovich FS, Darkhovskii MB, Gorbatova EN, Kurochkin VK. Molecular recognition: pharmacological aspects. 2004, Nova Science Publishers, New York. p 81. ISBN 1-59033-887-1
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- Pages with broken file links
- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Chemical articles without CAS Registry Number
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugboxes with an unspecified ATC code
- Drugs with no legal status
- Synthetic opioids
- Piperidines
- Carboxylate esters
- Propionamides
- Anilides
- Mu-opioid agonists