Oxycodone/naloxone

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Oxycodone/naloxone
Oxycodone.svg
Naloxone.svg
Combination of
Oxycodone Opioid analgesic
Naloxone Opioid receptor antagonist
Clinical data
AHFS/Drugs.com International Drug Names
UK Drug Information
Pregnancy
category
  • C
Legal status
Routes of
administration		 Oral
Identifiers
ATC code N02AA55 (WHO)
  (verify)

Oxycodone/naloxone is a combination analgesic drug available as modified-release tablets under the trade names Targin (produced by Mundipharma), Targiniq and Targinact.

The oxycodone component is an opioid and is responsible for the pain-relieving effects. Naloxone opposes the effects of opioids but is poorly absorbed into the body when given orally, meaning almost all the dose stays within the gastrointestinal tract and reduces the local side effects from the oxycodone. Constipation was significantly relieved in a 2008 study.[1] The drug was released in 2006 in Germany and is available in some other European countries since 2009.[2]

Adverse effects

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Further information: Oxycodone § Adverse effects

If the drug is used off license by crushing the tablet and dissolving it for injection, it may precipitate severe opiate withdrawal symptoms due to the much higher bioavailability of intravenous naloxone.

See also

References

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  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.



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